Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.33 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931575 | 0.92 | FNTA (0.36) | FNTAFNTBVDRGPBAR1CYP2C9 | |
| SCHEMBL9114171 | 0.86 | FAAH (0.38) | FNTAFNTBVDRGPBAR1CYP2C9 | |
| SCHEMBL7750346 | 0.81 | SRD5A1 (0.54) | SRD5A1SRD5A2 | |
| SCHEMBL7750342 | 0.81 | SRD5A1 (0.54) | SRD5A1SRD5A2 | |
| SCHEMBL8725587 | 0.80 | NR1H4 (0.36) | FNTAFNTBVDRGPBAR1CYP2C9 | |
| SCHEMBL9113792 | 0.80 | GPBAR1 (0.36) | VDRGPBAR1CYP2C9HIF1ASRD5A1 | |
| SCHEMBL9111199 | 0.80 | SRD5A2 (0.40) | FNTAFNTBVDRGPBAR1SRD5A1 | |
| SCHEMBL9113840 | 0.79 | GPBAR1 (0.36) | FNTAFNTBGPBAR1SRD5A2 | |
| SCHEMBL9113437 | 0.78 | SRD5A2 (0.36) | FNTAFNTBGPBAR1SRD5A2 | |
| SCHEMBL7745521 | 0.76 | RORC (0.36) | FNTAFNTBVDRGPBAR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710275-A | ENZYME AND HORMONE INHIBITORS | MERCK & CO., INC. (US) | 1998-01-20 | — | — | US | disclosed |
| EP-0778284-A2 | New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0572166-A1 | New 7beta-substituted-4-aza-5a-androstan-3-ones as 5a-reductase inhibitors | MERCK & CO. INC. (US) | 1993-12-01 | — | — | EP | disclosed |