Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 10/20 | 0.36 |
| ▸ | CTSS | P25774 | 7/20 | 0.36 |
| ▸ | CTSB | P07858 | 5/20 | 0.36 |
| ▸ | CTSK | P43235 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725848 | 0.83 | GPR139 (0.56) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9398221 | 0.81 | GPR139 (0.53) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL7716214 | 0.81 | GPR139 (0.53) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL6381157 | 0.78 | GPR139 (0.58) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL15962938 | 0.75 | GPR139 (0.59) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL17369074 | 0.73 | GPR139 (0.60) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL11098136 | 0.72 | GPR139 (0.54) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8726808 | 0.72 | — | — | |
| SCHEMBL8980464 | 0.71 | GPR139 (0.60) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8595095 | 0.70 | GPR139 (0.55) | GPR139KMT2AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756685-A | MEDICAL DIAGNOSIS; THERAPY | NEORX CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| US-5556982-A | Metal radionuclide labeled proteins for diagnosis and therapy | NEORX CORPORATION (US) | 1996-09-17 | — | — | US | disclosed |
| US-5242679-A | Complexes for imaging tumors | NEORX CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |
| US-5175343-A | For detection, radiotherapy and radeoimaging of tumors | NEORX CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |
| US-5120526-A | Chelate compounds | NEORX CORPORATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0188256-B1 | METAL RADIONUCLIDE LABELED PROTEINS FOR DIAGNOSIS AND THERAPY | NeoRx (US) | 1991-08-21 | — | — | EP | disclosed |
| US-5037630-A | Chelated polypeptides specific for tumors, improved imaging | NEORX CORPORATION (US) | 1991-08-06 | — | — | US | disclosed |
| US-4897255-A | Metal radionuclide labeled proteins for diagnosis and therapy | NEORX CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0188256-A2 | Metal radionuclide labeled proteins for diagnosis and therapy | NeoRx (US) | 1986-07-23 | — | — | EP | disclosed |