Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | PDXK | O00764 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11623305 | 0.97 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL29388363 | 0.83 | KDM4E (0.58) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL28265157 | 0.81 | TRIM24 (0.57) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5188886 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Hydrochloric Acid SCHEMBL2164217 | 0.80 | TRIM24 (0.55) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL26054339 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL13236377 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL29091174 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Tromethamine SCHEMBL11627160 | 0.74 | LMNA (0.48) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Trolamine SCHEMBL11621067 | 0.74 | KDM4E (0.47) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4070450-A | Sunscreening compound and method | HOFFMANN-LA ROCHE, INC. (US) | 1978-01-24 | — | — | US | claimed |
| US-5840654-A | COMBATING UNDESIRED PLANT GROWTH BY TREATING LOCUS WITH SPECIFIED HERBICIDE | AMERICAN CYANAMID COMPANY (US) | 1998-11-24 | — | — | US | disclosed |
| EP-0690846-B1 | HERBICIDAL HETEROCYCLIC-SUBSTITUTED PYRIDINES | SHELL INT RESEARCH (NL) | 1998-01-07 | — | — | EP | disclosed |
| EP-0537816-B1 | Herbicidal picolinamide derivatives | SHELL INT RESEARCH (NL) | 1996-04-24 | — | — | EP | disclosed |
| EP-0690846-A1 | HERBICIDAL HETEROCYCLIC-SUBSTITUTED PYRIDINES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1996-01-10 | — | — | EP | disclosed |
| US-5371061-A | Herbicidal picolinamide derivatives | AMERICAN CYANAMID COMPANY (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1994022833-A1 | HERBICIDAL HETEROCYCLIC-SUBSTITUTED PYRIDINES | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 1994-10-13 | — | — | WO | disclosed |
| EP-0537816-A1 | Herbicidal picolinamide derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1993-04-21 | — | — | EP | disclosed |
| US-4070450-A | Sunscreening compound and method | HOFFMANN-LA ROCHE, INC. (US) | 1978-01-24 | — | — | US | disclosed |