Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 6/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.40 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845353 | 0.92 | KDM4E (0.52) | KDM4ELMNAAPPHSD17B10ALDH1A1 | |
| SCHEMBL871785 | 0.90 | HCRTR1 (0.43) | KDM4ELMNAALDH1A1NPSR1GAA | |
| SCHEMBL845110 | 0.88 | ALDH1A1 (0.48) | KDM4ELMNAHSD17B10ALDH1A1KDM1A | |
| SCHEMBL873465 | 0.88 | KDM4E (0.47) | KDM4ELMNAAPPHSD17B10ALDH1A1 | |
| SCHEMBL845305 | 0.82 | GAA (0.58) | KDM4ELMNAALDH1A1TSHRL3MBTL1 | |
| SCHEMBL845279 | 0.81 | ALDH1A1 (0.53) | KDM4ELMNAAPPALDH1A1NPSR1 | |
| SCHEMBL845567 | 0.81 | ALDH1A1 (0.50) | KDM4ELMNAALDH1A1NPSR1GAA | |
| SCHEMBL845503 | 0.81 | SGMS2 (0.52) | KDM4ELMNAAPPHSD17B10ALDH1A1 | |
| SCHEMBL871691 | 0.80 | ALDH1A1 (0.44) | KDM4ELMNAHSD17B10ALDH1A1TSHR | |
| SCHEMBL845618 | 0.80 | MAPK1 (0.56) | LMNAALDH1A1NPSR1GAAPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |