Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725876 | 0.83 | HSD17B10 (0.42) | MAPTDHODHGRM4RAB9ANPC1 | |
| SCHEMBL5461423 | 0.82 | AURKA (0.41) | MAPTRAB9ANPC1MEN1LMNA | |
| SCHEMBL9379358 | 0.74 | MAPK10 (0.46) | MAPTMAPK10RAB9ANPC1MEN1 | |
| SCHEMBL5117827 | 0.73 | GPR55 (0.46) | MEN1KMT2A | |
| SCHEMBL27417170 | 0.72 | MAPT (0.63) | MAPTKCNH3DHODHMAPK10GRM4 | |
| SCHEMBL7546573 | 0.71 | KIF11 (0.52) | MAPTDHODHGRM4RAB9AMEN1 | |
| SCHEMBL9833566 | 0.71 | HTR3E (0.47) | GRM4NPC1KMT2A | |
| SCHEMBL3932390 | 0.68 | NPC1 (0.41) | MAPTKCNH3DHODHRAB9ANPC1 | |
| SCHEMBL1973038 | 0.68 | MAPK14 (0.36) | MAPTMAPK10RAB9ANPC1MEN1 | |
| SCHEMBL904437 | 0.68 | MAPK10 (0.59) | MAPTKCNH3MAPK10RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |