SCHEMBL8725779

SCHEMBL8725779

Clc1ccc2c(c1)Oc1ccccc1N2

nearest known ligand 0.79

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 7/20 0.65
AHR P35869 2/20 0.48
LMNA P02545 1/20 0.48
HTR2B P41595 2/20 0.47
TP53 P04637 1/20 0.46
MAPT P10636 1/20 0.46
CHEK1 O14757 1/20 0.45
BCHE P06276 2/20 0.44
ACHE P22303 2/20 0.44
NOX1 Q9Y5S8 1/20 0.44
HTR7 P34969 1/20 0.40
MAPK1 P28482 1/20 0.39
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17396556 0.90 AHR (0.58) ALOX5AHRLMNAHTR2BCHEK1
SCHEMBL6045366 0.89 ALOX5 (0.65) ALOX5AHRLMNAHTR2BTP53
Phenoxazine SCHEMBL7862 0.81 ALOX5 (1.00) ALOX5LMNAHTR2BMAPTHTR7
Phenoxazine SCHEMBL29355714 0.81 ALOX5 (1.00) ALOX5LMNAHTR2BMAPTHTR7
Phenoxazine SCHEMBL6310178 0.81 ALOX5 (1.00) ALOX5LMNAHTR2BMAPTHTR7
Phenoxazine SCHEMBL28844098 0.81 ALOX5 (1.00) ALOX5LMNAHTR2BMAPTHTR7
SCHEMBL11536640 0.81 ALOX5 (0.65) ALOX5AHRLMNAHTR2BTP53
SCHEMBL18333660 0.80 ALOX5 (0.71) ALOX5LMNAHTR2BMAPTHTR7
SCHEMBL7878578 0.80 LMNA (0.73) ALOX5LMNATP53MAPTCHEK1
SCHEMBL1366565 0.80 LMNA (0.58) ALOX5LMNATP53MAPTCHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192719-A1 ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT CANON KABUSHIKI KAISHA (JP) 2023-06-22 US disclosed
US-11524970-B2 Nitrogen-containing compound, electronic element, and electronic device SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2022-12-13 US disclosed
US-11524970-B2 Nitrogen-containing compound, electronic element, and electronic device SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2022-12-13 US disclosed
EP-3347355-B1 HETEROTRICYCLIC SULFONAMIDES AS ANTI-CANCER AGENTS ICAHN SCHOOL MED MOUNT SINAI (US) 2022-07-13 EP disclosed
EP-3347355-B1 HETEROTRICYCLIC SULFONAMIDES AS ANTI-CANCER AGENTS ICAHN SCHOOL MED MOUNT SINAI (US) 2022-07-13 EP disclosed
US-20220213124-A1 NITROGEN-CONTAINING COMPOUND, ELECTRONIC ELEMENT, AND ELECTRONIC DEVICE SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2022-07-07 US disclosed
US-20220213124-A1 NITROGEN-CONTAINING COMPOUND, ELECTRONIC ELEMENT, AND ELECTRONIC DEVICE SHAANXI LIGHTE OPTOELECTRONICS MATERIAL CO., LTD. (CN) 2022-07-07 US disclosed
CN-108349961-B Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents 西奈山伊坎医学院 2022-02-18 CN disclosed
CN-110903260-B Nitrogen-containing compound, electronic component, and electronic device 陕西莱特光电材料股份有限公司 2020-11-20 CN disclosed
US-10759790-B2 Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI (US) 2020-09-01 US disclosed
CN-101043918-A Cationic azacyanine dyes and colorants containing said dyes PROCTER & GAMBLE (US) 2007-09-26 CN disclosed
CN-1599591-A Hair treatment composition comprising composite particles of clay and charged organic molecule UNILEVER PLC (NL) 2005-03-23 CN disclosed
US-5756356-A COLORIMETRIC TOYO INK MANUFACTURING CO., LTD. (JP) 1998-05-26 US disclosed
US-4132794-A 10-Imidoylacridan compositions MEAD JOHNSON & COMPANY (US) 1979-01-02 US disclosed
US-4115571-A DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS MEAD JOHNSON & COMPANY (US) 1978-09-19 US disclosed
US-4094981-A SMOOTH MUSCLE RELAXANT EMPLOYING 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1978-06-13 US disclosed
US-4077959-A DIURETICS, SMOOTH MUSCLE RELAXANTS, ANTITHROMBOGENIC MEAD JOHNSON & COMPANY (US) 1978-03-07 US disclosed
US-4046891-A Smooth muscle relaxant process employing 10-imidoylphenoxazines MEAD JOHNSON & COMPANY (US) 1977-09-06 US disclosed
US-3962252-A 10-IMIDOYLACRIDANS MEAD JOHNSON & COMPANY (US) 1976-06-08 US disclosed
US-3946004-A DIURETICS, MUSCLE RELAXANTS, ANTITHROMBOGENIC AGENTS MEAD JOHNSON & COMPANY (US) 1976-03-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192719-A1 ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT OR10J3, CRY1, RPS19 ALOX5 2723/4885AHR 69/4885LMNA 3557/4885
US-10759790-B2 Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents FOXO1, HDAC3, HDAC6 ALOX5 4631/4885AHR 1441/4885LMNA 3439/4885
US-11524970-B2 Nitrogen-containing compound, electronic element, and electronic device OCIAD1, OCIAD2, JUND ALOX5 672/4885AHR 3188/4885LMNA 2691/4885
US-20220213124-A1 NITROGEN-CONTAINING COMPOUND, ELECTRONIC ELEMENT, AND ELECTRONIC DEVICE OCIAD1, OCIAD2, JUND ALOX5 672/4885AHR 3188/4885LMNA 2691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.