Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727211 | 0.83 | HRH3 (0.43) | HMOX1HRH3TP53ALDH1A1MEN1 | |
| SCHEMBL8727126 | 0.72 | CYP19A1 (0.55) | — | |
| SCHEMBL8722545 | 0.71 | SLC6A4 (0.49) | LTA4H | |
| SCHEMBL8723594 | 0.69 | HRH3 (0.44) | HRH3MAPK1LTA4HKDM4E | |
| SCHEMBL8722523 | 0.69 | TSHR (0.40) | ALDH1A1MAPK1LTA4HL3MBTL1 | |
| SCHEMBL6880513 | 0.69 | MEN1 (0.52) | HMOX1HRH3TP53ALDH1A1MEN1 | |
| SCHEMBL6880509 | 0.69 | ALDH1A1 (0.52) | HMOX1HRH3TP53ALDH1A1MEN1 | |
| SCHEMBL29788842 | 0.69 | RAB9A (0.52) | HMOX1HRH3TP53ALDH1A1MEN1 | |
| SCHEMBL8722517 | 0.68 | CYP11B1 (0.56) | MAPTPOLB | |
| SCHEMBL29788848 | 0.66 | HMOX1 (0.56) | HMOX1TP53ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |