Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727207 | 0.83 | HMOX1 (0.40) | HRH3ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6880513 | 0.73 | MEN1 (0.52) | HRH3ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL6880509 | 0.73 | ALDH1A1 (0.52) | HRH3ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL29788842 | 0.73 | RAB9A (0.52) | HRH3ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL5544578 | 0.71 | LPL (0.39) | ALDH1A1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL5543619 | 0.68 | HPGD (0.50) | ALDH1A1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL8727129 | 0.68 | CYP19A1 (0.55) | CYP2C9 | |
| SCHEMBL5543459 | 0.67 | UNG (0.48) | ALDH1A1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL5543937 | 0.67 | RAB9A (0.46) | ALDH1A1MEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL8722548 | 0.67 | KCNH2 (0.50) | HRH3POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |