Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.46 |
| ▸ | ACACA | Q13085 | 5/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758112 | 0.84 | TSHR (0.45) | CHRM4 | |
| SCHEMBL8733840 | 0.82 | CTSK (0.40) | ACACBACACA | |
| SCHEMBL8758776 | 0.79 | TSHR (0.47) | — | |
| SCHEMBL8729155 | 0.78 | NAMPT (0.43) | CA12CA1CA2CA9 | |
| SCHEMBL8729746 | 0.77 | CYP2C9 (0.47) | — | |
| SCHEMBL12648114 | 0.74 | EPHX1 (0.55) | ACACBDRD2SIRT2SIRT1SIRT3 | |
| SCHEMBL4703208 | 0.74 | CHRM4 (0.56) | ACACBACACADRD2CKS1BSKP1 | |
| SCHEMBL17675706 | 0.72 | CA12 (0.67) | IDO1KDM4EPKMCA12CA1 | |
| SCHEMBL32665296 | 0.72 | CHRM4 (0.56) | CHRM4 | |
| SCHEMBL803459 | 0.72 | ACHE (0.67) | CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726165-A | HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-03-10 | — | — | US | disclosed |