SCHEMBL8729641

SCHEMBL8729641

Cc1cccc(N2CC(C)(C)C(=O)N2)c1C

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADRB1 P08588 1/20 0.41
RECQL P46063 1/20 0.40
ALOX5 P09917 2/20 0.40
ALDH1A1 P00352 4/20 0.39
MAPT P10636 2/20 0.39
OPRM1 P35372 1/20 0.39
ADAMTS5 Q9UNA0 1/20 0.39
NPSR1 Q6W5P4 1/20 0.38
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
HCAR1 Q9BXC0 2/20 0.37
LMNA P02545 2/20 0.36
DDB1 Q16531 1/20 0.36
CRBN Q96SW2 1/20 0.36
HTT P42858 1/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8735393 0.87 ALOX5 (0.53) ADRB1RECQLALOX5ALDH1A1MAPT
SCHEMBL11289404 0.76 MGLL (0.40) RECQLALOX5ALDH1A1MAPTDDB1
SCHEMBL8904250 0.76 GAA (0.39) ALOX5ALDH1A1MAPTNPSR1TSHR
SCHEMBL8729644 0.75 NPSR1 (0.42) ALDH1A1MAPTOPRM1NPSR1HCAR1
SCHEMBL11871019 0.74 MGLL (0.42) ALDH1A1MAPTNPSR1MAPK1HCAR1
SCHEMBL8751387 0.72 ALOX5 (0.56) ADRB1ALOX5ALDH1A1MAPTOPRM1
SCHEMBL271530 0.71 G6PD (0.55) ALOX5ALDH1A1MAPT
SCHEMBL5179391 0.70 ALOX5 (0.50) ALOX5ALDH1A1MAPTOPRM1MAPK1
SCHEMBL10606044 0.69 MAPT (0.37) ALDH1A1MAPTADAMTS5LMNAHTT
SCHEMBL9471567 0.69 ALOX5 (0.54) ADRB1RECQLALOX5ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5804359-A OPTICAL DENSITY PROVIDED BY SILVER; HIGHER MOLAR RATIO OF REDUCING AGENT TO SILVER HALIDE IN THE FIRST EMULSION LAYER THAN IN THE SECOND, FOR IMPROVED SIGNAL TO NOISE. EASTMAN KODAK COMPANY (US) 1998-09-08 US disclosed
US-5633126-A Films for reproducing digitally stored medical diagnostic images and integrating non-image information EASTMAN KODAK COMPANY (US) 1997-05-27 US disclosed
EP-0014594-B1 PHOTOGRAPHIC IMAGE REVERSAL PROCESS AND PHOTOGRAPHIC ELEMENT FOR USE THEREIN KODAK LIMITED (GB) 1983-07-27 EP disclosed
US-4258117-A ELECTRON TRANSFER AGENT, CROSS-OXIDATION EASTMAN KODAK COMPANY (US) 1981-03-24 US disclosed