Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 7/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8731991 | 0.80 | PSMB1 (0.46) | MMP3PSMB1CTSLCTSKCASP1 | |
| SCHEMBL9064404 | 0.79 | CTSL (0.50) | MMP3PSMB1CTSLCASP1MME | |
| SCHEMBL18735868 | 0.78 | PSMB1 (0.56) | PSMB1CTSLCTSKTACR1MME | |
| SCHEMBL11124167 | 0.78 | MME (0.64) | PSMB1CTSLCTSKTACR1MME | |
| SCHEMBL7270223 | 0.78 | PSMB1 (0.59) | PSMB1CTSLCTSKTACR1MME | |
| SCHEMBL722757 | 0.78 | MME (0.62) | PSMB1CTSKTACR1CASP1MME | |
| SCHEMBL3569541 | 0.78 | MME (0.62) | PSMB1CTSKTACR1CASP1MME | |
| SCHEMBL7688519 | 0.78 | PSMB1 (0.57) | PSMB1CTSLCTSKTACR1CASP1 | |
| SCHEMBL8955765 | 0.78 | CTSL (0.57) | PSMB1CTSLCTSKTACR1CASP1 | |
| SCHEMBL1491365 | 0.78 | MME (0.62) | PSMB1CTSKTACR1CASP1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708004-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | MONSANTO COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| US-5703076-A | TREATING HIV, AIDS | G. D. SEARLE & CO. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5698569-A | Retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5510349-A | HUMAN IMMUNODEFICIENCY VIRUS | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |
| US-5510378-A | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1996-04-23 | — | — | US | disclosed |