Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25629999 | 0.89 | ALDH1A1 (0.50) | CYP11B2CYP11B1HTR1APDE3BPDE3A | |
| SCHEMBL24865360 | 0.86 | GABRA5 (0.46) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL762347 | 0.85 | CYP11B2 (0.51) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL13591353 | 0.77 | NR1H2 (0.40) | ALDH1A1NPC1LMNAMAPK1CASP3 | |
| SCHEMBL13406065 | 0.77 | HTR1A (0.52) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL30336271 | 0.75 | GABRG2 (0.46) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL24865349 | 0.75 | GABRG2 (0.46) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL8738573 | 0.74 | CYP11B1 (0.45) | CYP11B2CYP11B1ALDH1A1LMNAPOLB | |
| SCHEMBL5985192 | 0.74 | CYP11B2 (0.55) | CYP11B2CYP11B1HTR1AHTR2CPDE3B | |
| SCHEMBL762019 | 0.74 | ALDH1A1 (0.61) | CYP11B2CYP11B1HTR1APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129867-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129867-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK1 | CYP11B2 1337/4885CYP11B1 1249/4885HTR1A 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.