Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL6927596 | 0.87 | TDP1 (0.43) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL1997201 | 0.85 | TDP1 (0.44) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL29414132 | 0.85 | TDP1 (0.44) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL7023211 | 0.85 | DRD2 (0.42) | DRD2DRD3DRD1DRD4DRD5 | |
| Hydrogen Sulfide SCHEMBL4225727 | 0.84 | TDP1 (0.43) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL16926997 | 0.84 | DRD2 (0.41) | DRD2DRD3DRD1DRD4DRD5 | |
| Iodide SCHEMBL8735171 | 0.83 | SLC22A12 (0.49) | DRD2AKR1C3AKR1C2DRD3DRD1 | |
| Iodide SCHEMBL1286189 | 0.80 | DRD2 (0.37) | DRD2DRD3DRD1DRD4DRD5 | |
| Iodide SCHEMBL8735164 | 0.78 | DRD2 (0.40) | DRD2DRD3DRD1DRD4DRD5 | |
| Diphenylsulfane SCHEMBL1996327 | 0.78 | TDP1 (0.38) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697387-B1 | Improved method for the preparation of iodonium salts | DOW CORNING (US) | 1998-04-22 | — | — | EP | disclosed |