Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7203972 | 0.67 | CYP2D6 (0.38) | CYP2D6HDAC4PDK2MGLL | |
| Hydrochloric Acid SCHEMBL8342938 | 0.65 | ACHE (0.35) | HDAC4 | |
| Water SCHEMBL5700740 | 0.61 | GABRA1 (0.55) | CYP2D6MGLL | |
| Hydrochloric Acid SCHEMBL3889855 | 0.60 | ELANE (0.34) | — | |
| SCHEMBL25425763 | 0.59 | GABRA1 (0.58) | CYP2D6MGLL | |
| SCHEMBL29390847 | 0.59 | GABRA1 (0.58) | CYP2D6MGLL | |
| SCHEMBL36294 | 0.59 | GABRA1 (0.58) | CYP2D6MGLL | |
| SCHEMBL20114472 | 0.58 | HDAC4 (0.45) | CYP2D6HDAC4PDK2MGLL | |
| SCHEMBL23933927 | 0.58 | HDAC4 (0.49) | CYP2D6HDAC4PDK2 | |
| SCHEMBL149221 | 0.57 | CYP2D6 (0.41) | CYP2D6HDAC4PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703245-B1 | Olefin polymerization catalyst and process for olefin polymerization | MITSUI CHEMICALS INC (JP) | 1998-05-20 | — | — | EP | disclosed |
| EP-0703245-A2 | Olefin polymerization catalyst and process for olefin polymerization | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-27 | — | — | EP | disclosed |