Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28744387 | 0.87 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2CASP3KMT2A | |
| SCHEMBL8544187 | 0.85 | CASP3 (0.49) | ALDH1A1SMN1; SMN2CASP3KMT2APKM | |
| SCHEMBL18974296 | 0.83 | TGM2 (0.57) | ALDH1A1MAPT | |
| SCHEMBL15584122 | 0.83 | CASP3 (0.45) | ALDH1A1MAPTSMN1; SMN2CASP3KMT2A | |
| SCHEMBL2527719 | 0.82 | CASP3 (0.48) | ALDH1A1CASP3RAB9AGRM5 | |
| SCHEMBL1854606 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MAPTSMN1; SMN2CASP3NOX4 | |
| SCHEMBL9030149 | 0.78 | PRKAG1 (0.53) | ALDH1A1CASP3 | |
| SCHEMBL6166132 | 0.78 | MMP2 (0.47) | ALDH1A1MAPTCASP3KMT2AMEN1 | |
| SCHEMBL13627952 | 0.77 | ALDH1A1 (0.41) | ALDH1A1CYP19A1MAPTSMN1; SMN2NOX4 | |
| SCHEMBL1630498 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTKMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| EP-2640731-B9 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-11-25 | — | — | EP | disclosed |
| EP-2640731-B1 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | LUNDBECK & CO AS H (DK) | 2015-07-08 | — | — | EP | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-9062060-B2 | Substituted imidazo[2,1-A]isoindoles as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2015-06-23 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | H. LUNDBECK A/S (DK) | 2014-12-04 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8796304-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2014-08-05 | — | — | US | disclosed |
| US-8673890-B2 | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-18 | — | — | US | disclosed |
| US-8552045-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2013-10-08 | — | — | US | disclosed |
| US-8552045-B2 | Tricyclic imidazole compounds as PDE10 inhibitors | H. LUNDBECK A/S (DK) | 2013-10-08 | — | — | US | disclosed |
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | US | disclosed |
| WO-2012065612-A1 | IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS | H. LUNDBECK A/S (DK) | 2012-05-24 | — | — | WO | disclosed |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129836-A1 | Imidazole derivatives as PDE10A enzyme inhibitors | PDE5A, PDE3A, PDE3B | ALDH1A1 80/4885CYP19A1 289/4885MAPT 136/4885 |
| US-20140357639-A1 | Imidazole derivatives as PDE10 enzyme inhibitors | PDE12, PDE5A, PDE10A | ALDH1A1 113/4885CYP19A1 303/4885MAPT 160/4885 |
| US-20110105490-A1 | 2,3-DIHYDRO-1H-ISOINDOL-1-IMINE DERIVATIVES USEFUL AS THROMBIN PAR-1 RECEPTOR ANTAGONIST | F2R, F2RL1, F2RL3 | ALDH1A1 1921/4885CYP19A1 1433/4885MAPT 3412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.