Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873709 | 0.92 | CHRNA7 (0.41) | CHRNA7NAMPTDRD2DRD3ALDH1A1 | |
| SCHEMBL874535 | 0.91 | NAMPT (0.48) | CHRNA7NAMPTDRD2DRD3ALDH1A1 | |
| SCHEMBL874135 | 0.91 | NAMPT (0.41) | CHRNA7NAMPTDRD2DRD3ALDH1A1 | |
| SCHEMBL873905 | 0.86 | DRD2 (0.48) | CHRNA7NAMPTDRD2DRD3ALDH1A1 | |
| SCHEMBL873865 | 0.83 | NAMPT (0.42) | CHRNA7NAMPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL874187 | 0.83 | NPC1 (0.46) | CHRNA7ALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874023 | 0.82 | CHRNA7 (0.42) | CHRNA7NAMPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL873871 | 0.81 | NPC1 (0.42) | CHRNA7NAMPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL874184 | 0.79 | NPC1 (0.41) | CHRNA7NAMPTALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL874680 | 0.77 | NPC1 (0.46) | ALDH1A1SMN1; SMN2HSD17B10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |