Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | SI | P14410 | 2/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873871 | 0.87 | NPC1 (0.42) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL874184 | 0.84 | NPC1 (0.41) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL874187 | 0.84 | NPC1 (0.46) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL874185 | 0.83 | NPC1 (0.39) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL873865 | 0.80 | NAMPT (0.42) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL874535 | 0.80 | NAMPT (0.48) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL873866 | 0.79 | CHRNA7 (0.42) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL874536 | 0.79 | NAMPT (0.45) | NPC1RAB9AKDM4ESMN1; SMN2GAA | |
| SCHEMBL873905 | 0.78 | DRD2 (0.48) | ALDH1A1 | |
| SCHEMBL873709 | 0.78 | CHRNA7 (0.41) | NPC1RAB9AKDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |