Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8741546 | 0.86 | HDAC2 (0.51) | HDAC2LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL11077453 | 0.80 | KLK7 (0.52) | HDAC2LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL10989929 | 0.76 | KLK7 (0.67) | HDAC2LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL29101367 | 0.75 | MEN1 (0.54) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7589113 | 0.75 | ALDH1A1 (0.53) | LMNATSHRMAPTALDH1A1ATM | |
| SCHEMBL7591938 | 0.73 | TSHR (0.34) | LMNATSHRMAPTSMN1; SMN2 | |
| SCHEMBL3955546 | 0.72 | HDAC2 (0.51) | HDAC2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8153169 | 0.72 | HDAC2 (0.76) | HDAC2LMNAHDAC3HDAC4HDAC1 | |
| SCHEMBL3960647 | 0.71 | SIRT1 (0.59) | HDAC2LMNAKLK7 | |
| SCHEMBL18530333 | 0.71 | POLB (0.52) | HDAC2LMNAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5628980-A | Nonionic radiographic contrast agents | BRACCO INTERNATIONAL B.V. (NL) | 1997-05-13 | — | — | US | disclosed |
| US-5614638-A | Nonionic radiographic contrast agents | BRACCO INTERNATIONAL B.V. (NL) | 1997-03-25 | — | — | US | disclosed |
| US-5591846-A | Nonionic radiographic contrast agents | BRACCO INTERNATIONAL B.V. | 1997-01-07 | — | — | US | disclosed |
| US-5559237-A | Process for preparation of 2-oxo-1-piperidinyl derivatives | BRACCO INTERNATIONAL B.V. (NL) | 1996-09-24 | — | — | US | disclosed |
| US-5359077-A | Process for preparation of 2-oxo-1 piperidinyl derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0573289-A2 | Process for preparation of 2-oxo-1-piperidinyl derivatives | BRACCO INTERNATIONAL B.V. (NL) | 1993-12-08 | — | — | EP | disclosed |