SCHEMBL8744137

SCHEMBL8744137

COc1ccc(N=C2CCC(O)CC2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.42
HTR3E A5X5Y0 1/20 0.42
HTR3B O95264 1/20 0.42
HTR3A P46098 1/20 0.42
HTR3D Q70Z44 1/20 0.42
HTR3C Q8WXA8 1/20 0.42
PTGS2 P35354 1/20 0.39
MAPK1 P28482 1/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38
GRM3 Q14832 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
SLC18A3 Q16572 1/20 0.37
ALDH1A1 P00352 3/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8744024 0.84 MAOA (0.45) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL8744014 0.83 PTGS2 (0.39) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL8743983 0.83 CA12 (0.38) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL8743915 0.80 MAPT (0.41) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL8743927 0.80 NPC1 (0.46) NOS3CA1CA2MAPTALOX12
SCHEMBL8743907 0.78 ESR2 (0.44) NOS3CA12CA1CA2CA9
SCHEMBL8743958 0.78 ALDH1A1 (0.49) NOS3HTR3EHTR3BHTR3AHTR3D
SCHEMBL8743928 0.77 SLC22A2 (0.36) NOS3ALDH1A1MAPTKDM4EMPI
SCHEMBL13657829 0.76 MAPT (0.49) MAPK1CA1CA2L3MBTL1ALDH1A1
SCHEMBL7790490 0.74 NOS3 (0.43) NOS3HTR3EHTR3BHTR3AHTR3D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618980-A DEHYDROGENATING N-CYCLOHEXYLIDENEAMINO COMPOUND IN PRESENCE OF HYDROGEN TRANSFER CATALYST AND HYDROGEN ACCEPTOR AND ALKALI OR ALKALINE EARTH METAL COMPOUND COCATALYST MITSUI TOATSU CHEMICALS, INC. (JP) 1997-04-08 US disclosed
EP-0588060-B1 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
EP-0753505-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1997-01-15 EP disclosed
US-5536878-A HYDROGEN ACCEPTOR MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-16 US disclosed
US-5382690-A Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-01-17 US disclosed
EP-0588060-A2 Method for preparing aromatic secondary amino compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-03-23 EP disclosed