Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1896769 | 0.98 | ALDH1A1 (0.48) | ALDH1A1TSHRTHRBMAPTNPSR1 | |
| SCHEMBL27438786 | 0.84 | TSHR (0.42) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL28791986 | 0.82 | TSHR (0.44) | ALDH1A1TSHRTHRBATM | |
| SCHEMBL9746132 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRTHRBMAPTNPSR1 | |
| SCHEMBL8582053 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRTHRBMAPTNPSR1 | |
| SCHEMBL9746477 | 0.82 | ALDH1A1 (0.52) | ALDH1A1TSHRTHRBMAPTNPSR1 | |
| SCHEMBL27789803 | 0.81 | THRB (0.41) | ALDH1A1TSHRTHRBLMNAHSD17B10 | |
| SCHEMBL9746066 | 0.81 | TSHR (0.53) | ALDH1A1TSHRTHRBNPSR1LMNA | |
| SCHEMBL28185686 | 0.80 | TSHR (0.52) | ALDH1A1TSHRTHRBNPSR1 | |
| SCHEMBL9747120 | 0.80 | ALDH1A1 (0.45) | ALDH1A1TSHRTHRBMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5625050-A | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics | AMGEN INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0753002-A1 | MODIFIED OLIGONUCLEOTIDES AND INTERMEDIATES USEFUL IN NUCLEIC ACID THERAPEUTICS | AMGEN INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026972-A1 | MODIFIED OLIGONUCLEOTIDES AND INTERMEDIATES USEFUL IN NUCLEIC ACID THERAPEUTICS | AMGEN INC. (US) | 1995-10-12 | — | — | WO | disclosed |