Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.45 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SDCBP | O00560 | 3/20 | 0.43 |
| ▸ | SDC2 | P34741 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744706 | 1.00 | THRA (0.45) | THRATHRBPYGLCYP2C9SDCBP | |
| SCHEMBL8744757 | 0.88 | KMT2A (0.54) | PYGLCYP2C9KMT2AGFERMEN1 | |
| SCHEMBL8744747 | 0.88 | KMT2A (0.54) | PYGLCYP2C9KMT2AGFERMEN1 | |
| SCHEMBL7094314 | 0.88 | MAPK1 (0.44) | THRATHRBPYGLCYP2C9KMT2A | |
| SCHEMBL7094315 | 0.88 | MAPK1 (0.44) | THRATHRBPYGLCYP2C9KMT2A | |
| SCHEMBL6996743 | 0.87 | THRA (0.47) | THRATHRBSDCBPSDC2KMT2A | |
| SCHEMBL6996747 | 0.87 | THRA (0.47) | THRATHRBSDCBPSDC2KMT2A | |
| SCHEMBL8744751 | 0.85 | PYGL (0.48) | THRATHRBPYGLCYP2C9KMT2A | |
| SCHEMBL8744745 | 0.85 | PYGL (0.48) | THRATHRBPYGLCYP2C9KMT2A | |
| SCHEMBL9594891 | 0.85 | TAS1R3 (0.49) | THRBCYP2C9KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |