Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744730 | 1.00 | PYGL (0.47) | PYGLCYP2C9CYP2C19SLC22A12CA2 | |
| SCHEMBL4421060 | 0.89 | ALDH1A1 (0.45) | PYGLCYP2C9CYP2C19CA2CA1 | |
| SCHEMBL4421059 | 0.89 | ALDH1A1 (0.45) | PYGLCYP2C9CYP2C19CA2CA1 | |
| SCHEMBL8744811 | 0.87 | SDCBP (0.51) | SLC22A12AKR1B1KMT2AALDH1A1POLB | |
| SCHEMBL8744816 | 0.87 | SDCBP (0.51) | SLC22A12AKR1B1KMT2AALDH1A1POLB | |
| SCHEMBL8744750 | 0.85 | ALDH1A1 (0.48) | SLC22A12AKR1B1KMT2AALDH1A1HTT | |
| SCHEMBL9595704 | 0.85 | ALDH1A1 (0.48) | SLC22A12AKR1B1KMT2AALDH1A1HTT | |
| SCHEMBL27384185 | 0.81 | ALDH1A1 (0.53) | PYGLCYP2C9CYP2C19CA2CA1 | |
| SCHEMBL8744794 | 0.81 | AKR1B1 (0.53) | SLC22A12AKR1B1KMT2AALDH1A1ATM | |
| SCHEMBL8744800 | 0.81 | AKR1B1 (0.53) | SLC22A12AKR1B1KMT2AALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |