Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876377 | 0.77 | CHRNA7 (0.47) | CHRNA7KMT2ANPC1RAB9AF10 | |
| SCHEMBL876612 | 0.76 | CHRNA7 (0.46) | CHRNA7KMT2ANPC1RAB9AF10 | |
| SCHEMBL874498 | 0.73 | ACKR3 (0.43) | HTR3A | |
| SCHEMBL874187 | 0.71 | NPC1 (0.46) | CHRNA7KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL10065068 | 0.71 | ACKR3 (0.39) | NPC1RAB9AHTR3AALDH1A1MAPT | |
| SCHEMBL874291 | 0.71 | CHRNA7 (0.39) | CHRNA7KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL873877 | 0.70 | CHRNA7 (0.42) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL874709 | 0.70 | CA12 (0.43) | KMT2AALDH1A1MAPT | |
| SCHEMBL5516018 | 0.69 | MAPT (0.58) | CHRNA7KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL882752 | 0.69 | NAMPT (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |