Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.43 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10065068 | 0.86 | ACKR3 (0.39) | ACKR3LMNASMYD3HTR3A | |
| SCHEMBL874709 | 0.84 | CA12 (0.43) | KHK | |
| SCHEMBL882752 | 0.77 | NAMPT (0.46) | — | |
| SCHEMBL874577 | 0.73 | CHRNA7 (0.45) | HTR3A | |
| SCHEMBL4294367 | 0.67 | ALDH1A1 (0.52) | LMNA | |
| SCHEMBL717648 | 0.66 | L3MBTL1 (0.58) | — | |
| SCHEMBL876773 | 0.66 | LRRK2 (0.42) | BMPR1BBMPR1ATGFBR1ACVRL1ACVR1 | |
| SCHEMBL30583805 | 0.65 | RAB9A (0.62) | LMNAHRH3SMYD3MAPK14 | |
| SCHEMBL3442327 | 0.65 | RAB9A (0.62) | LMNAHRH3SMYD3MAPK14 | |
| SCHEMBL875174 | 0.65 | NPC1 (0.40) | LMNASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |