Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746111 | 0.88 | LDHA (0.46) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL8746134 | 0.86 | IDO1 (0.44) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL16690673 | 0.86 | TP53 (0.48) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL8746191 | 0.85 | HTT (0.55) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL20435394 | 0.84 | HTT (0.44) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL8746120 | 0.82 | CA1 (0.46) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL9973241 | 0.82 | IDO1 (0.44) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL20425139 | 0.82 | ALDH1A1 (0.46) | IDO1MEN1KMT2ALDHAEPHX1 | |
| SCHEMBL25018885 | 0.81 | HTT (0.48) | IDO1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL20425141 | 0.80 | ALDH1A1 (0.39) | IDO1MEN1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155258-B1 | IMPROVED PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9493485-B2 | Spirocyclic dihydro-thiazine and dihydro-oxazine BACE inhibitors, and compositions and uses thereof | IMAGO PHARMACEUTICALS, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160272654-A1 | SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | IMAGO PHARMACEUTICALS, INC. (US) | 2016-09-22 | — | — | US | disclosed |
| US-9227924-B2 | Processes for making hydrazides | WYETH LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150307518-A1 | SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | ELAN PHARMACEUTICALS, INC. | 2015-10-29 | — | — | US | disclosed |
| US-20150099865-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2015-04-09 | — | — | US | disclosed |
| US-20150087825-A1 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | XU YING-ZI (US) | 2015-03-26 | — | — | US | disclosed |
| US-20150087826-A1 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | XU YING-ZI (US) | 2015-03-26 | — | — | US | disclosed |
| US-8853451-B2 | Processes for making hydrazides | WYETH LLC (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130211053-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2013-08-15 | — | — | US | disclosed |
| US-8383857-B2 | Processes for making hydrazides | WYETH LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120130052-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2012-05-24 | — | — | US | disclosed |
| US-8110705-B2 | Processes for making hydrazides | WYETH LLC (US) | 2012-02-07 | — | — | US | disclosed |
| US-20080312422-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312422-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | IDO1 4053/4885MEN1 2514/4885KMT2A 1111/4885 |
| US-20120130052-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | IDO1 4053/4885MEN1 2514/4885KMT2A 1111/4885 |
| US-20130211053-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | IDO1 4053/4885MEN1 2514/4885KMT2A 1111/4885 |
| US-20150099865-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | IDO1 4053/4885MEN1 2514/4885KMT2A 1111/4885 |
| US-20150087826-A1 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | BACE1, BACE2, APP | IDO1 1554/4885MEN1 1250/4885KMT2A 3689/4885 |
| US-20150087825-A1 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | BACE1, BACE2, APP | IDO1 1554/4885MEN1 1250/4885KMT2A 3689/4885 |
| US-20160272654-A1 | SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | BACE1, BACE2, APP | IDO1 2069/4885MEN1 1308/4885KMT2A 3352/4885 |
| US-20150307518-A1 | SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF | BACE1, BACE2, APP | IDO1 2069/4885MEN1 1308/4885KMT2A 3352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.