Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8746191 | 0.87 | HTT (0.55) | MEN1KMT2AHTTGAAIDO1 | |
| SCHEMBL8746178 | 0.86 | IDO1 (0.45) | TP53MEN1KMT2AHTTGAA | |
| SCHEMBL16692027 | 0.86 | MAPT (0.43) | TP53MEN1KMT2AMAPTNPC1 | |
| SCHEMBL8746111 | 0.86 | LDHA (0.46) | MEN1KMT2AHTTIDO1F2RL1 | |
| SCHEMBL8746134 | 0.85 | IDO1 (0.44) | MEN1KMT2AHTTIDO1F2RL1 | |
| SCHEMBL8746120 | 0.84 | CA1 (0.46) | MEN1KMT2AHTTGAAIDO1 | |
| SCHEMBL25018885 | 0.83 | HTT (0.48) | MEN1KMT2AHTTGAAIDO1 | |
| SCHEMBL20435394 | 0.82 | HTT (0.44) | MEN1KMT2AHTTGAAIDO1 | |
| SCHEMBL20425141 | 0.82 | ALDH1A1 (0.39) | TP53MEN1KMT2AHTTGAA | |
| SCHEMBL9973241 | 0.81 | IDO1 (0.44) | MEN1KMT2AHTTIDO1F2RL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11576981-B2 | Acyl hydrazone linkers, methods and uses thereof | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2023-02-14 | — | — | US | disclosed |
| US-20210106694-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2021-04-15 | — | — | US | disclosed |
| US-20200397916-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2020-12-24 | — | — | US | disclosed |
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2019-12-17 | — | — | US | disclosed |
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2018-05-17 | — | — | US | disclosed |
| US-9902691-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | PFIZER INC. (US) | 2018-02-27 | — | — | US | disclosed |
| US-9872922-B2 | Anti-EFNA4 antibody-drug conjugates | PFIZER INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170072066-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | PFIZER, INC. (US) | 2017-03-16 | — | — | US | disclosed |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2016-09-01 | — | — | US | disclosed |
| US-9381205-B2 | Anti-EFNA4 antibody-drug conjugates | PFIZER, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150125472-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | STEM CENTRX, INC. (US) | 2015-05-07 | — | — | US | disclosed |
| WO-2015063680-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | PFIZER INC. (US) | 2015-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10508081-B2 | Intermediates and methods for synthesizing calicheamicin derivatives | CALR, CALD1, CYCS | TP53 2630/4885MEN1 3898/4885KMT2A 4788/4885 |
| US-20160251389-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | TP53 2630/4885MEN1 3898/4885KMT2A 4788/4885 |
| US-20210106694-A1 | HETEROCYCLIC ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | HDAC6, C9, AADAC | TP53 3682/4885MEN1 876/4885KMT2A 606/4885 |
| US-20180134656-A1 | INTERMEDIATES AND METHODS FOR SYNTHESIZING CALICHEAMICIN DERIVATIVES | CALR, CALD1, CYCS | TP53 2630/4885MEN1 3898/4885KMT2A 4788/4885 |
| US-20170072066-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | EFNA1, ACTN4, AFF4 | TP53 3254/4885MEN1 3636/4885KMT2A 2007/4885 |
| US-20200397916-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | KAT7, AADAC, HDAC7 | TP53 3920/4885MEN1 1615/4885KMT2A 1440/4885 |
| US-20150125472-A1 | ANTI-EFNA4 ANTIBODY-DRUG CONJUGATES | EFNA1, ACTN4, AFF4 | TP53 3254/4885MEN1 3636/4885KMT2A 2007/4885 |
| US-11576981-B2 | Acyl hydrazone linkers, methods and uses thereof | AADAC, HDAC8, KAT8 | TP53 4093/4885MEN1 1412/4885KMT2A 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.