Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25018885 | 0.93 | HTT (0.48) | HTTTDP1MEN1KMT2AMAPT | |
| SCHEMBL8746120 | 0.89 | CA1 (0.46) | HTTMEN1KMT2AMAPTGAA | |
| SCHEMBL16690673 | 0.87 | TP53 (0.48) | HTTMEN1KMT2AMAPTGAA | |
| SCHEMBL8746178 | 0.85 | IDO1 (0.45) | HTTMEN1KMT2AMAPTGAA | |
| SCHEMBL8746111 | 0.85 | LDHA (0.46) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL8746134 | 0.84 | IDO1 (0.44) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL20435394 | 0.81 | HTT (0.44) | HTTTDP1MEN1KMT2AMAPT | |
| SCHEMBL9973241 | 0.80 | IDO1 (0.44) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL21544515 | 0.79 | SMN1; SMN2 (0.58) | HTTMEN1KMT2AMAPTGAA | |
| SCHEMBL6604781 | 0.78 | KMT2A (0.56) | HTTMEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2465541-B1 | Improved processes for making hydrazides | WYETH LLC (US) | 2018-07-18 | — | — | EP | disclosed |
| US-9738602-B2 | Processes for making hydrazides | WYETH LLC (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738602-B2 | Processes for making hydrazides | WYETH LLC (US) | 2017-08-22 | — | — | US | disclosed |
| EP-2155258-B1 | IMPROVED PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2017-08-16 | — | — | EP | disclosed |
| US-20160176809-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2016-06-23 | — | — | US | disclosed |
| US-20160176809-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2016-06-23 | — | — | US | disclosed |
| US-9227924-B2 | Processes for making hydrazides | WYETH LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-9227924-B2 | Processes for making hydrazides | WYETH LLC (US) | 2016-01-05 | — | — | US | disclosed |
| US-20150099865-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2015-04-09 | — | — | US | disclosed |
| US-20150099865-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2015-04-09 | — | — | US | disclosed |
| US-8853451-B2 | Processes for making hydrazides | WYETH LLC (US) | 2014-10-07 | — | — | US | disclosed |
| US-8853451-B2 | Processes for making hydrazides | WYETH LLC (US) | 2014-10-07 | — | — | US | disclosed |
| US-20130211053-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2013-08-15 | — | — | US | disclosed |
| US-20130211053-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2013-08-15 | — | — | US | disclosed |
| US-8383857-B2 | Processes for making hydrazides | WYETH LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-8383857-B2 | Processes for making hydrazides | WYETH LLC (US) | 2013-02-26 | — | — | US | disclosed |
| US-20120130052-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH LLC (US) | 2012-05-24 | — | — | US | disclosed |
| US-8110705-B2 | Processes for making hydrazides | WYETH LLC (US) | 2012-02-07 | — | — | US | disclosed |
| US-20080312422-A1 | PROCESSES FOR MAKING HYDRAZIDES | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312422-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | HTT 844/4885TDP1 4844/4885MEN1 2514/4885 |
| US-20120130052-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | HTT 844/4885TDP1 4844/4885MEN1 2514/4885 |
| US-20130211053-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | HTT 844/4885TDP1 4844/4885MEN1 2514/4885 |
| US-20160176809-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | HTT 844/4885TDP1 4844/4885MEN1 2514/4885 |
| US-20150099865-A1 | PROCESSES FOR MAKING HYDRAZIDES | CALU, CALD1, ACR | HTT 844/4885TDP1 4844/4885MEN1 2514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.