Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575981 | 0.86 | MEN1 (0.54) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL9800592 | 0.83 | CYP1A2 (0.54) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL8376336 | 0.82 | MEN1 (0.47) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL8746111 | 0.81 | LDHA (0.46) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL16690673 | 0.79 | TP53 (0.48) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL2430380 | 0.79 | MEN1 (0.45) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL8746191 | 0.78 | HTT (0.55) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL21544515 | 0.78 | SMN1; SMN2 (0.58) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL8746178 | 0.78 | IDO1 (0.45) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL5757662 | 0.77 | LDHA (0.49) | HTTSMN1; SMN2ACENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399420-A2 | PYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SmithKline Beecham Corporation (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002530-A2 | PYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |