Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8747148 | 0.86 | PKM (0.55) | PKMKMT2AMEN1TSHRDRD1 | |
| SCHEMBL8747254 | 0.85 | PKM (0.46) | PKMKMT2AMEN1TSHRDRD1 | |
| Hydrochloric Acid SCHEMBL8747055 | 0.70 | PKM (0.54) | PKMKMT2AMEN1TSHRMAOA | |
| SCHEMBL8747147 | 0.69 | PKM (0.46) | PKMKMT2AMEN1SLC6A9 | |
| SCHEMBL8747203 | 0.68 | PKM (0.47) | PKMKMT2AMEN1TSHRDRD1 | |
| SCHEMBL8747215 | 0.68 | PKM (0.54) | PKMKMT2AMEN1TSHRMAOA | |
| SCHEMBL8747118 | 0.68 | PKM (0.54) | PKMKMT2AMEN1TSHRMAOA | |
| SCHEMBL8747329 | 0.68 | PKM (0.45) | PKMKMT2AMEN1 | |
| SCHEMBL8747282 | 0.67 | SLC6A9 (0.51) | PKMKMT2AMEN1TSHRMAOA | |
| SCHEMBL8747173 | 0.67 | MAOA (0.47) | KMT2AMEN1DRD1DRD5MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618900-B1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1997-03-12 | — | — | EP | disclosed |
| US-5519034-A | ANALGESICS | THE BOOTS COMPANY PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| WO-1993013073-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES AND THEIR USE AS THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |