SCHEMBL8747878

SCHEMBL8747878

COC12CCC(c3cc[c]cc3)(CC1)CC2

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.32
HSD11B1 P28845 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748114 0.79 PNMT (0.33) PNMT
SCHEMBL10316602 0.72 OPRM1 (0.40)
SCHEMBL8747764 0.72 L3MBTL1 (0.37)
SCHEMBL8747861 0.72 IDO1 (0.42)
SCHEMBL8098112 0.70 PNMT (0.32) PNMT
SCHEMBL8748112 0.69 CYP4A11 (0.41)
SCHEMBL7026052 0.69 PNMT (0.31) PNMT
SCHEMBL8747881 0.68 HDAC4 (0.40) PNMTHSD11B1
SCHEMBL9251161 0.66 HSD11B1 (0.30) HSD11B1
SCHEMBL9251166 0.66 GSK3B (0.43) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0599732-B1 Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them ADIR (FR) 1997-03-12 EP disclosed
EP-0599732-A1 Derivatives of 1-phenylbicyclo-2,2,2-octane, their preparation process and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1994-06-01 EP disclosed