Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 11/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875702 | 0.87 | NAMPT (0.44) | HDAC1NAMPTPOLBMAPKAPK2 | |
| SCHEMBL874795 | 0.85 | NAMPT (0.47) | HDAC1NAMPT | |
| SCHEMBL875591 | 0.82 | NAMPT (0.46) | HDAC1NAMPTDGAT1KLKB1 | |
| SCHEMBL874757 | 0.82 | HDAC1 (0.44) | HDAC1NAMPTDGAT1KLKB1 | |
| SCHEMBL874763 | 0.77 | NAMPT (0.43) | HDAC1NAMPTPOLBFLT3TYRO3 | |
| SCHEMBL874752 | 0.76 | NAMPT (0.52) | HDAC1NAMPTPOLB | |
| SCHEMBL3048653 | 0.74 | TYRO3 (0.51) | FLT3TYRO3MERTKGAS6 | |
| SCHEMBL875947 | 0.73 | PPARA (0.49) | HDAC1NAMPTPOLB | |
| SCHEMBL874398 | 0.73 | NAMPT (0.50) | HDAC1NAMPT | |
| SCHEMBL3050217 | 0.73 | HDAC1 (0.47) | HDAC1NAMPTFLT3TYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |