Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | NAMPT | P43490 | 12/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875591 | 0.83 | NAMPT (0.46) | HDAC1NAMPTDGAT1KLKB1 | |
| SCHEMBL875577 | 0.82 | HDAC1 (0.43) | HDAC1NAMPTDGAT1KLKB1 | |
| SCHEMBL874429 | 0.79 | CDC7 (0.42) | — | |
| SCHEMBL874763 | 0.76 | NAMPT (0.43) | HDAC1NAMPTROCK2 | |
| SCHEMBL874752 | 0.75 | NAMPT (0.52) | HDAC1NAMPT | |
| SCHEMBL883122 | 0.75 | NAMPT (0.43) | HDAC1NAMPTKLKB1ROCK2 | |
| SCHEMBL3050217 | 0.73 | HDAC1 (0.47) | HDAC1NAMPTROCK2 | |
| SCHEMBL875947 | 0.72 | PPARA (0.49) | HDAC1NAMPT | |
| SCHEMBL874692 | 0.72 | NAMPT (0.53) | HDAC1NAMPT | |
| SCHEMBL874398 | 0.72 | NAMPT (0.50) | HDAC1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |