Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21625555 | 0.86 | CTSD (0.63) | CASP6ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL2648700 | 0.86 | MAPK1 (0.58) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL28512713 | 0.86 | ALDH1A1 (0.55) | CASP6ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL1252136 | 0.86 | LMNA (0.68) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL11654108 | 0.85 | CASP6 (0.67) | CASP6ALDH1A1MAPTHTTTDP1 | |
| SCHEMBL16446085 | 0.85 | ALDH1A1 (0.53) | CASP6ALDH1A1MAPTMAPK1HTT | |
| SCHEMBL5180766 | 0.85 | TSHR (0.66) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL31387585 | 0.85 | TSHR (0.66) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL13495683 | 0.85 | TSHR (0.66) | ALDH1A1MAPTMAPK1HTTSMN1; SMN2 | |
| SCHEMBL1483661 | 0.83 | ALDH1A1 (0.56) | CASP6ALDH1A1MAPTMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0581904-B1 | METHOD OF INHIBITING FIBROSIS | UNIV DUKE (US) | 1997-05-28 | — | — | EP | disclosed |
| US-5571846-A | Method of inhibiting fibrosis | DUKE UNIVERSITY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5374660-A | Asministering a benzoic hydrazide to treat antigrowth of fibroblasts, fibronectins, collagen | DUKE UNIVERSITY (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0581904-A4 | METHOD OF INHIBITING FIBROSIS | UNIV DUKE (US) | 1994-05-25 | — | — | EP | disclosed |
| EP-0581904-A1 | METHOD OF INHIBITING FIBROSIS. | UNIV DUKE (US) | 1994-02-09 | — | — | EP | disclosed |
| WO-1992017065-A2 | METHOD OF INHIBITING FIBROSIS | DUKE UNIVERSITY (US) | 1992-10-15 | — | — | WO | disclosed |
| US-4309422-A | INSECTICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |