SCHEMBL8760127

SCHEMBL8760127

COc1ccc(C2(c3ccc(O)cc3)CCCCC2)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 5/20 0.71
ESR1 P03372 4/20 0.71
LTA4H P09960 1/20 0.52
BACE1 P56817 2/20 0.50
SLC6A4 P31645 2/20 0.50
SLC6A3 Q01959 2/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIN2B Q13224 1/20 0.50
APP P05067 2/20 0.47
ALDH1A1 P00352 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
CALM1 P0DP23 1/20 0.44
GAA P10253 1/20 0.44
PKM P14618 1/20 0.44
PSMB1 P20618 1/20 0.43
PSMB5 P28074 1/20 0.43
PSMB2 P49721 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25986515 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL19268518 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL10112726 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL10086337 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL10112733 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL10112736 0.91 SLC6A4 (0.58) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL23968910 0.89 ESR2 (0.57) ESR2ESR1LTA4HBACE1SLC6A4
SCHEMBL12808406 0.89 BACE1 (0.57) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL21085480 0.85 ESR1 (0.77) ESR2ESR1BACE1SLC6A4SLC6A3
SCHEMBL13379655 0.84 ESR2 (1.00) ESR2ESR1SLC6A4SLC6A3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11693329-B2 Fluorine-containing resin particle, composition, layer-shaped article, electrophotographic photoreceptor, process cartridge, and image forming apparatus FUJIFILM BUSINESS INNOVATION CORP. (JP) 2023-07-04 US disclosed
US-11333987-B2 Fluorine-containing resin particle, composition, layer-shaped article, electrophotographic photoreceptor, process cartridge, and image forming apparatus FUJIFILM BUSINESS INNOVATION CORP. (JP) 2022-05-17 US disclosed
US-20220066335-A1 FLUORINE-CONTAINING RESIN PARTICLE, COMPOSITION, LAYER-SHAPED ARTICLE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJIFILM BUSINESS INNOVATION CORP. (JP) 2022-03-03 US disclosed
US-11186545-B2 Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof TRIOPTOTEC GMBH (DE) 2021-11-30 US disclosed
US-20200257210-A1 FLUORINE-CONTAINING RESIN PARTICLE, COMPOSITION, LAYER-SHAPED ARTICLE, ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2020-08-13 US disclosed
US-10452021-B2 Process cartridge and electrophotographic image forming apparatus CANON KABUSHIKI KAISHA (JP) 2019-10-22 US disclosed
US-10429754-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2019-10-01 US disclosed
US-10338485-B2 Electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2019-07-02 US disclosed
US-20190163120-A1 PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-05-30 US disclosed
US-10209638-B2 Electrophotographic photosensitive member KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2019-02-19 US disclosed
US-9846378-B2 Electrophotographic photoreceptor, process cartridge, image forming apparatus, and conductive substrate that may be included in electrophotographic photoreceptor FUJI XEROX CO., LTD. (JP) 2017-12-19 US disclosed
US-20170261874-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, IMAGE FORMING APPARATUS, AND CONDUCTIVE SUBSTRATE THAT MAY BE INCLUDED IN ELECTROPHOTOGRAPHIC PHOTORECEPTOR FUJI XEROX CO., LTD. (JP) 2017-09-14 US disclosed
US-9760029-B2 Electrophotographic photosensitive member, image forming apparatus, and process cartridge KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-09-12 US disclosed
US-20170153560-A1 NAPHTHALENEDICARBOXIMIDE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER KYOCERA DOCUMENT SOLUTIONS INC. (JP) 2017-06-01 US disclosed
EP-2681627-B1 PROCESS FOR PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER CANON KK (JP) 2017-05-10 EP disclosed
EP-2633370-B1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2017-04-26 EP disclosed
US-9069268-B2 Polyarylatecarbonate fluoropolymer containing photoconductors XEROX CORPORATION (US) 2015-06-30 US disclosed
US-20150079511-A1 POLYARYLATECARBONATE FLUOROPOLYMER CONTAINING PHOTOCONDUCTORS XEROX CORPORATION (US) 2015-03-19 US disclosed
EP-0497465-B1 Record material APPLETON PAPER INC (US) 1997-06-04 EP disclosed
EP-0497465-A1 Record material APPLETON PAPERS INC. (US) 1992-08-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170153560-A1 NAPHTHALENEDICARBOXIMIDE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER CRY1, CRY2, CCNT1 ESR2 1156/4885ESR1 1460/4885LTA4H 2690/4885
US-11186545-B2 Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof PYCR1, CRY1, PPOX ESR2 1806/4885ESR1 1725/4885LTA4H 3271/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.