Sugi Predict

Sugi Predict / Compounds / SCHEMBL876189

SCHEMBL876189

SCHEMBL876189

O=C(O)c1ccc(C2=NOC(c3ccc(F)c(C(F)(F)F)c3)(C(F)(F)F)C2)c2ccccc12

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ KMO O15229 2/20 0.32
▸ CXCR5 P32302 1/20 0.32
▸ RORC P51449 4/20 0.32
▸ RPS6KB1 P23443 1/20 0.32
▸ DHODH Q02127 1/20 0.32
▸ AKR1C3 P42330 1/20 0.31
▸ AKR1C2 P52895 1/20 0.31
▸ GRM4 Q14833 1/20 0.31
▸ KCNN4 O15554 2/20 0.31
▸ GRIK1 P39086 1/20 0.31
▸ TTR P02766 1/20 0.31
▸ PPARG P37231 1/20 0.31
▸ RARA P10276 1/20 0.31
▸ RARB P10826 1/20 0.31
▸ RARG P13631 1/20 0.31
▸ VNN1 O95497 1/20 0.31
▸ ASPH Q12797 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL876196 0.90 KCNN4 (0.36) CA1CA2RPS6KB1GRM4KCNN4
SCHEMBL872468 0.89 CA1 (0.32) CA1CA2RORCDHODHAKR1C3
SCHEMBL10072347 0.88 CA1 (0.35) CA1CA2CXCR5RORCRARA
SCHEMBL869742 0.88 PDK2 (0.36) CA1CA2CXCR5DHODHAKR1C3
SCHEMBL878385 0.87 GPR52 (0.37) CXCR5RPS6KB1
SCHEMBL871473 0.86 P2RX7 (0.32) CA1CA2CXCR5RPS6KB1GRM4
SCHEMBL878386 0.86 RPS6KB1 (0.34) RPS6KB1KCNN4
SCHEMBL10316194 0.85 TYMS (0.35) CA1CA2CXCR5
SCHEMBL871441 0.85 PDK2 (0.37) RORCDHODHGRIK1
SCHEMBL871382 0.84 PDK2 (0.36) CA1CA2DHODHGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2619189-B1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS ZOETIS SERVICES LLC (US) 2020-04-15 — — EP disclosed
EP-2619189-B1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS ZOETIS SERVICES LLC (US) 2020-04-15 — — EP disclosed
EP-2619189-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS Zoetis LLC (US) 2013-07-31 — — EP disclosed
US-8404649-B2 Isoxazoline oximes as antiparasitic agents AH USA 42 LLC (US) 2013-03-26 — — US disclosed
US-8404649-B2 Isoxazoline oximes as antiparasitic agents AH USA 42 LLC (US) 2013-03-26 — — US disclosed
US-20120077765-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS PFIZER INC. (US) 2012-03-29 — — US disclosed
US-20120077765-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS PFIZER INC. (US) 2012-03-29 — — US disclosed
WO-2012038851-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS PFIZER INC. (US) 2012-03-29 — — WO disclosed
WO-2012038851-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS PFIZER INC. (US) 2012-03-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077765-A1 ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS CYP1A2, CYP3A7, CYP2E1 CA1 2008/4885CA2 1391/4885KMO 401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.