Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL878508 | 0.87 | F10 (0.34) | F10CCR5MCHR1POLB | |
| SCHEMBL876131 | 0.86 | POLB (0.34) | F10CCR5MCHR1POLB | |
| SCHEMBL875758 | 0.86 | F10 (0.34) | F10CCR5MCHR1ROCK2POLB | |
| SCHEMBL876160 | 0.80 | F10 (0.33) | F10NPC1RAB9ACCR5MCHR1 | |
| SCHEMBL876267 | 0.78 | F10 (0.36) | F10NPC1RAB9ACCR5KDM4C | |
| SCHEMBL878362 | 0.78 | TLR9 (0.36) | F10POLB | |
| SCHEMBL876159 | 0.77 | NPC1 (0.35) | F10NPC1RAB9ACCR5KDM4C | |
| SCHEMBL784870 | 0.77 | F10 (0.42) | F10NPC1RAB9ACCR5ROCK2 | |
| SCHEMBL784756 | 0.74 | F10 (0.40) | F10NPC1RAB9ACCR5KDM4C | |
| SCHEMBL785183 | 0.73 | F10 (0.39) | F10NPC1RAB9ACCR5ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | claimed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | claimed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |