SCHEMBL8764131

SCHEMBL8764131

Cc1ccc(C(CN=C=S)CN=C=S)cc1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MIF P14174 9/20 0.49
TRPA1 O75762 4/20 0.41
CHRNA7 P36544 1/20 0.34
ALDH1A1 P00352 1/20 0.32
CYP3A4 P08684 1/20 0.32
HPGD P15428 1/20 0.32
ACHE P22303 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP2E1 P05181 1/20 0.31
CYP2A6 P11509 1/20 0.31
HIF1A Q16665 1/20 0.31
CYP2A13 Q16696 1/20 0.31
EPAS1 Q99814 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8763999 0.79 MIF (0.48) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL6956846 0.73 MIF (0.53) MIFTRPA1ALDH1A1CYP3A4HPGD
Toluene SCHEMBL28790216 0.71 TRPA1 (0.61) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL1706732 0.68 MIF (0.63) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL4079934 0.68 MIF (0.42) MIFTRPA1CHRNA7ALDH1A1ACHE
SCHEMBL11345905 0.68 MIF (0.42) MIFTRPA1CHRNA7ALDH1A1ACHE
SCHEMBL8987427 0.67 MIF (0.40) MIFTRPA1ALDH1A1CYP3A4HPGD
SCHEMBL3989199 0.66 ADRA2A (0.48) CHRNA7ALDH1A1CYP3A4ACHETDP1
SCHEMBL8764025 0.66 ESR1 (0.50) CHRNA7ALDH1A1CYP3A4HPGDACHE
SCHEMBL3364900 0.65 MIF (0.66) MIFTRPA1CYP2E1CYP2A6HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0349195-B1 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC (US) 1997-05-21 EP disclosed
US-5629394-A ENDCAPPING ADDITION POLYMERS WITH NITROGEN FUNCTIONAL GROUPS WHICH CAN BE FURTHER DERIVATIZED EXXON CHEMICAL PATENTS INC (US) 1997-05-13 US disclosed
US-5444135-A Polymerization and functionalization with nitrogen-containing functional groups occur simultaneously EXXON CHEMICAL PATENTS INC. (US) 1995-08-22 US disclosed
US-5336745-A Terminally-substituted polymeric compositions from cationically polymerizable monomers and initiators EXXON CHEMICAL PATENTS INC. (US) 1994-08-09 US disclosed
US-5032653-A Catalysts EXXON CHEMICAL PATENTS, INC. (US) 1991-07-16 US disclosed
EP-0349195-A2 Direct synthesis by cationic polymerization of nitrogen-containing polymers EXXON CHEMICAL PATENTS INC. (US) 1990-01-03 EP disclosed