Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874617 | 0.83 | DRD2 (0.44) | CHRNA7NAMPTDRD2DRD3 | |
| SCHEMBL873609 | 0.81 | MAPT (0.45) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL875382 | 0.80 | NPC1 (0.40) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL874482 | 0.80 | CHRM4 (0.42) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL874618 | 0.78 | NAMPT (0.41) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL874187 | 0.78 | NPC1 (0.46) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL874730 | 0.77 | NPC1 (0.39) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL874483 | 0.75 | RAB9A (0.40) | CHRNA7NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL876377 | 0.73 | CHRNA7 (0.47) | CHRNA7NPC1RAB9AKMT2APOLB | |
| SCHEMBL876612 | 0.72 | CHRNA7 (0.46) | CHRNA7NPC1RAB9AKMT2ARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |