SCHEMBL8767485

SCHEMBL8767485

Cc1nc(-c2ccccc2)cc(=O)n1C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.56
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
TP53 P04637 3/20 0.53
KDM4E B2RXH2 2/20 0.53
RAD51 Q06609 1/20 0.53
ADORA1 P30542 1/20 0.49
GSK3B P49841 4/20 0.48
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
CGAS Q8N884 1/20 0.46
MAPT P10636 1/20 0.46
KDM5B Q9UGL1 1/20 0.46
BACE1 P56817 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CDC7 O00311 1/20 0.46
ROCK2 O75116 1/20 0.46
MAP4K4 O95819 1/20 0.46
PIM1 P11309 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4493177 0.81 BACE1 (0.63) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL7385338 0.79 GSK3B (0.59) ALDH1A1GSK3BMEN1KMT2ACDC7
SCHEMBL11502325 0.78 ADORA1 (0.56) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL8994051 0.77 GSK3B (0.56) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL28499587 0.75 ALDH1A1 (0.49) ALDH1A1GSK3B
SCHEMBL8994033 0.74 ALDH1A1 (0.48) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL10686873 0.74 TDP2 (0.49) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL4508981 0.72 BACE1 (0.67) KDM4EBACE1
SCHEMBL8756013 0.72 KMT2A (0.59) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL11797265 0.71 ALDH1A1 (1.00) ALDH1A1NPC1RAB9ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0654035-B1 PHOSPHONOACETIC ESTERS AND ACIDS AS ANTI-INFLAMMATORIES UPJOHN CO (US) 1997-08-20 EP disclosed
EP-0521622-B1 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories UPJOHN CO (US) 1997-08-13 EP disclosed
US-5643895-A Phosphonoacetic esters and acids as anti-inflammatories THE UPJOHN COMPANY (US) 1997-07-01 US disclosed
EP-0593575-B1 PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES UPJOHN CO (US) 1997-05-07 EP disclosed
US-5565441-A AN N-HETEROCYCLE DERIVATIVE; ANTIARTHRITIC AGENTS; DISEASES CHARACTERIZED BY ABNORMAL PHOSPHATE AND CALCIUM METABOLISM; CHRONIC DISEASES THE UPJOHN COMPANY (US) 1996-10-15 US disclosed
EP-0654035-A1 PHOSPHONOACETIC ESTERS AND ACIDS AS ANTI-INFLAMMATORIES. UPJOHN CO (US) 1995-05-24 EP disclosed
US-5397774-A Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories THE UPJOHN COMPANY (US) 1995-03-14 US disclosed
EP-0593575-A1 PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES. UPJOHN CO (US) 1994-04-27 EP disclosed
WO-1994003463-A1 PHOSPHONOACETIC ESTERS AND ACIDS AS ANTI-INFLAMMATORIES THE UPJOHN COMPANY (US) 1994-02-17 WO disclosed
WO-1993001198-A1 PYRAZOLOPYRIMIDINE AND PYRIMIDINYL BISPHOSPHONIC ESTERS AS ANTI-INFLAMMATORIES THE UPJOHN COMPANY (US) 1993-01-21 WO disclosed
EP-0521622-A1 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories THE UPJOHN COMPANY (US) 1993-01-07 EP disclosed