Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10527436 | 0.87 | ATM (0.43) | TDP1L3MBTL1TSHRGPR35MGLL | |
| SCHEMBL4609556 | 0.78 | TSHR (0.54) | TDP1L3MBTL1TSHRKDM4EGLA | |
| SCHEMBL8697187 | 0.75 | SMN1; SMN2 (0.46) | L3MBTL1TSHRKDM4EGLAHCAR3 | |
| SCHEMBL1554602 | 0.75 | TDP1 (0.75) | TDP1L3MBTL1TSHRGPR35MEN1 | |
| SCHEMBL3393314 | 0.74 | TSHR (0.53) | TDP1L3MBTL1TSHRKDM4EGLA | |
| SCHEMBL10620627 | 0.74 | NPSR1 (0.53) | TDP1L3MBTL1TSHRGPR35MGLL | |
| SCHEMBL11551945 | 0.74 | PDE7A (0.44) | L3MBTL1TSHRMEN1KMT2ALMNA | |
| SCHEMBL3392826 | 0.72 | DTYMK (0.49) | TSHRKDM4EGLAPOLBMGLL | |
| SCHEMBL7968895 | 0.72 | ALDH1A1 (0.43) | L3MBTL1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL7909935 | 0.72 | MEN1 (0.52) | TSHRKDM4EPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792366-A1 | ENZYME GENE THERAPY CATALYSING PRODRUG EXTRACELLULAR CONVERSION | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-09-03 | — | — | EP | disclosed |
| WO-1996016179-A1 | ENZYME GENE THERAPY CATALYSING PRODRUG EXTRACELLULAR CONVERSION | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-05-30 | — | — | WO | disclosed |