Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28333843 | 0.72 | CTSB (0.42) | LOXTSHRLMNAHSD11B1BCAT2 | |
| SCHEMBL23162797 | 0.71 | HSD11B1 (0.48) | LMNACA2MAOAMAOBHSD11B1 | |
| SCHEMBL8106699 | 0.70 | LOX (0.47) | LOXLMNACA2HSD11B1BCAT2 | |
| SCHEMBL10180103 | 0.68 | PTGS2 (0.55) | LMNAHSD11B1 | |
| SCHEMBL14472622 | 0.68 | LMNA (0.37) | LMNAHSD11B1BCAT2 | |
| SCHEMBL10192344 | 0.67 | PTGS2 (0.58) | LMNAMEN1KMT2AHSD11B1 | |
| SCHEMBL8522289 | 0.66 | CTSB (0.34) | LOXTSHRLMNAHSD11B1BCAT2 | |
| SCHEMBL27593793 | 0.66 | AR (0.46) | TSHRLMNACA2MAOAMAOB | |
| SCHEMBL6606000 | 0.64 | HTR2C (0.56) | — | |
| SCHEMBL7988825 | 0.63 | CA2 (0.42) | TSHRLMNACA2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |