SCHEMBL8771907

SCHEMBL8771907

CC(C)[C@H](N)C(=O)N(C(=O)OC(C)(C)C)C(C)COc1ccccn1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.37
SLC1A5 Q15758 2/20 0.36
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
GRM2 Q14416 1/20 0.32
CYP1A2 P05177 1/20 0.32
POLB P06746 1/20 0.31
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
SSTR4 P31391 1/20 0.31
PSMB5 P28074 1/20 0.30
CYP2C19 P33261 2/20 0.30
GHSR Q92847 2/20 0.30
CYP3A4 P08684 1/20 0.30
TP53 P04637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8772011 0.77 MTNR1A (0.33)
SCHEMBL8771956 0.77 GHSR (0.33) NPC1RAB9ASMN1; SMN2POLBGHSR
SCHEMBL8772017 0.77 MMP2 (0.46)
SCHEMBL8772008 0.76 GPR119 (0.40)
SCHEMBL8771998 0.75 GAA (0.44) SMN1; SMN2CYP1A2CYP3A4
SCHEMBL8771782 0.75 ADRB3 (0.31)
SCHEMBL8772001 0.75 TSHR (0.32) TSHRCYP1A2CYP2C19CYP3A4
Hydrochloric Acid SCHEMBL3827873 0.72 TSHR (0.37) TSHRSLC1A5NPC1RAB9ASMN1; SMN2
SCHEMBL8771852 0.71 SMN1; SMN2 (0.42) RAB9ASMN1; SMN2CYP1A2CYP2C19CYP3A4
SCHEMBL10423913 0.69 AKT1 (0.42) POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648740-B1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-10-08 EP disclosed