SCHEMBL8772001

SCHEMBL8772001

CC(C)[C@H](N)C(=O)N(C(=O)OC(C)(C)C)C(C)COc1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.32

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
BDKRB1 P46663 1/20 0.30
SCN4A P35499 2/20 0.30
AHR P35869 1/20 0.30
KDM4E B2RXH2 2/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
HPGD P15428 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
CYP3A4 P08684 2/20 0.30
CYP1A2 P05177 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30
NFKB1 P19838 1/20 0.30
CYP2C19 P33261 1/20 0.30
AAK1 Q2M2I8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8772011 0.81 MTNR1A (0.33) HPGDAAK1
SCHEMBL8771852 0.78 SMN1; SMN2 (0.42) KDM4EALDH1A1GAACYP3A4CYP1A2
SCHEMBL8771956 0.76 GHSR (0.33) KDM4EGAAHPGDNPSR1
SCHEMBL8772017 0.76 MMP2 (0.46) ALDH1A1HPGD
SCHEMBL8771907 0.75 TSHR (0.37) TSHRCYP3A4CYP1A2CYP2C19
SCHEMBL8772008 0.75 GPR119 (0.40)
SCHEMBL8771998 0.74 GAA (0.44) ALDH1A1GAACYP3A4CYP1A2
SCHEMBL8771782 0.74 ADRB3 (0.31) AAK1
SCHEMBL8772004 0.67 MMP2 (0.45) ALDH1A1HPGD
SCHEMBL8771761 0.67 MMP2 (0.44) ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648740-B1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-10-08 EP disclosed