SCHEMBL8771997

SCHEMBL8771997

CC(Oc1ccc(C#N)cc1)C(C)N(C(=O)OC(C)(C)C)C(=O)[C@@H](N)C(C)C

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
GPR119 Q8TDV5 1/20 0.34
NR3C1 P04150 1/20 0.33
MMP2 P08253 3/20 0.33
TRPA1 O75762 1/20 0.33
PARP15 Q460N3 1/20 0.33
PARP10 Q53GL7 1/20 0.33
PARP2 Q9UGN5 1/20 0.33
MMP3 P08254 1/20 0.32
ABCB1 P08183 7/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
MAOB P27338 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA4 P43681 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8771878 0.85 MMP13 (0.33) GAA
SCHEMBL8772017 0.83 MMP2 (0.46) GPR119MMP2MMP3ALDH1A1MAPT
SCHEMBL8771877 0.82 GAA (0.39) GAASMN1; SMN2ALDH1A1MAPT
SCHEMBL8772004 0.75 MMP2 (0.45) MMP2MMP3ALDH1A1MAPTMAOB
SCHEMBL8771913 0.75 MMP2 (0.46) MMP2MMP3ALDH1A1MAPTMAOB
SCHEMBL8771761 0.74 MMP2 (0.44) GPR119MMP2MMP3ALDH1A1MAPT
SCHEMBL8898675 0.72 ALOX5 (0.38) GPR119ABCB1
SCHEMBL8771989 0.71 MMP2 (0.45) GPR119MMP2MMP3ALDH1A1MAPT
SCHEMBL8771956 0.68 GHSR (0.33) GAASMN1; SMN2GPR119MAPTMAOB
SCHEMBL8772008 0.67 GPR119 (0.40) GPR119MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648740-B1 AMINO ACID AMIDE DERIVATIVE, AGROHORTICULTURAL BACTERICIDE, AND PRODUCTION PROCESS KUMIAI CHEMICAL INDUSTRY CO (JP) 1997-10-08 EP disclosed