Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | HRH2 | P25021 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | MMP13 | P45452 | 5/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8772629 | 0.97 | SIGMAR1 (0.43) | SIGMAR1HRH3HRH2HRH1MMP13 | |
| SCHEMBL8417820 | 0.87 | FDFT1 (0.37) | MMP13 | |
| SCHEMBL8968385 | 0.85 | MMP13 (0.39) | MMP13 | |
| Hydrochloric Acid SCHEMBL8418615 | 0.84 | FDFT1 (0.37) | MMP13 | |
| Hydrochloric Acid SCHEMBL8968667 | 0.75 | LTA4H (0.42) | HRH3MMP13 | |
| Hydrochloric Acid SCHEMBL8422025 | 0.75 | LTA4H (0.44) | HRH3 | |
| SCHEMBL8594298 | 0.74 | CHRM2 (0.48) | — | |
| SCHEMBL8969436 | 0.70 | MMP13 (0.38) | MMP13 | |
| SCHEMBL227294 | 0.69 | HRH3 (0.45) | SIGMAR1HRH3HRH2HRH1TRPM8 | |
| SCHEMBL14292185 | 0.67 | KMT2A (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |