SCHEMBL8772740

SCHEMBL8772740

COc1ccc(C2(c3ccc(OC)cc3)C=Cc3c4c(c5cc(Cl)cc(Cl)c5c3O2)-c2cc(OS(C)(=O)=O)c(OC)cc2C4(C)C)cc1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF4A1 P60842 1/20 0.32
NFE2L2 Q16236 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8829991 0.92 EIF4A1 (0.31) EIF4A1
SCHEMBL6113483 0.89 EIF4A1 (0.32) EIF4A1
SCHEMBL6113902 0.88
SCHEMBL9934040 0.85 HTR6 (0.31) EIF4A1
SCHEMBL1187814 0.82 CA12 (0.32) EIF4A1
SCHEMBL30708909 0.82 CA12 (0.33)
SCHEMBL3698200 0.82 CA12 (0.33)
SCHEMBL5648722 0.80 EIF4A1 (0.33) EIF4A1
SCHEMBL20752592 0.79
SCHEMBL4568624 0.76 MAPT (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9309455-B2 Indeno-fused ring compounds TRANSITIONS OPTICAL, INC. (US) 2016-04-12 US disclosed
US-20140166948-A1 INDENO-FUSED RING COMPOUNDS TRANSITIONS OPTICAL LIMITED (IE) 2014-06-19 US disclosed
US-20120126185-A1 INDENO-FUSED RING COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-05-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120126185-A1 INDENO-FUSED RING COMPOUNDS CRY2, SQOR, INTS6 EIF4A1 1748/4885NFE2L2 214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.