SCHEMBL8773192

SCHEMBL8773192

FC(F)(F)c1cccc(Oc2cc(Cl)cc(Oc3cccc(C(F)(F)F)c3)n2)c1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.52
L3MBTL1 Q9Y468 2/20 0.51
ALDH1A1 P00352 2/20 0.51
POLB P06746 1/20 0.51
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.49
LRRK2 Q5S007 1/20 0.48
ADORA2A P29274 1/20 0.48
PPARG P37231 3/20 0.48
NTRK1 P04629 1/20 0.47
GAA P10253 1/20 0.46
P2RY1 P47900 1/20 0.46
TEAD1 P28347 2/20 0.45
KDM4E B2RXH2 1/20 0.44
LOX P28300 1/20 0.44
LOXL2 Q9Y4K0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7108376 0.88 MAPT (0.58) MAPTL3MBTL1ALDH1A1POLBLRRK2
SCHEMBL29607042 0.86 MAPT (0.65) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL8773158 0.86 MAPT (0.65) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL8507324 0.84 MAPT (0.56) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL3457474 0.83 MAPT (0.58) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL8773209 0.83 MAPT (0.58) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL7110627 0.82 MAPT (0.74) MAPTL3MBTL1ALDH1A1POLBPPARG
SCHEMBL8550799 0.81 L3MBTL1 (0.45) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL17608849 0.81 ALDH1A1 (0.51) MAPTL3MBTL1ALDH1A1POLBCYP1A2
SCHEMBL7891911 0.81 TEAD1 (0.54) MAPTL3MBTL1ALDH1A1POLBCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691277-A REACTING A 2,6-DIHALOGENOPYRIDINE WITH A META SUBSTITUTED PHENOL KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-11-25 US disclosed
EP-0692474-B1 2- (unsubstituted or substituted) (benzyloxy or phenoxy)-4-substituted-6-(meta-substituted phenoxy) pyridine, process for producing the same, and herbicidal composition KUREHA CHEMICAL IND CO LTD (JP) 1997-10-29 EP disclosed
EP-0692474-A1 2- (unsubstituted or substituted) (benzyloxy or phenoxy)-4-substituted-6-(meta-substituted phenoxy) pyridine, process for producing the same, and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-01-17 EP disclosed