SCHEMBL8773948

SCHEMBL8773948

CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)OC(C)=O)c1I

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.58
SMN1; SMN2 Q16637 1/20 0.40
ALDH1A1 P00352 2/20 0.32
TSHR P16473 1/20 0.32
KDM4E B2RXH2 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
IDO1 P14902 1/20 0.31
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9852541 0.85 LMNA (0.61) LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2
SCHEMBL8773943 0.84 LMNA (0.56) LMNASMN1; SMN2KDM4ECYP1A2CYP2C9
SCHEMBL9102086 0.81 LMNA (0.58) LMNASMN1; SMN2ALDH1A1KDM4ECYP1A2
SCHEMBL8512366 0.80 LMNA (0.49) LMNASMN1; SMN2ALDH1A1TSHRKDM4E
SCHEMBL5682572 0.80 LMNA (0.56) LMNASMN1; SMN2KDM4ECYP1A2CYP2C9
SCHEMBL10875389 0.79 LMNA (0.68) LMNASMN1; SMN2ALDH1A1TSHRKDM4E
SCHEMBL9413251 0.79 LMNA (0.54) LMNASMN1; SMN2ALDH1A1TSHRCYP1A2
SCHEMBL332859 0.79 LMNA (0.54) LMNASMN1; SMN2ALDH1A1TSHRKDM4E
SCHEMBL22680970 0.78 LMNA (0.68) LMNASMN1; SMN2ALDH1A1TSHRKDM4E
SCHEMBL9016334 0.77 LMNA (0.53) LMNASMN1; SMN2ALDH1A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0804161-A1 CONTINUOUS METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES NanoSystems L.L.C. (US) 1997-11-05 EP disclosed
EP-0760653-A1 METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES NanoSystems L.L.C. (US) 1997-03-12 EP disclosed
EP-0756497-A1 X-RAY CONTRAST COMPOSITIONS CONTAINING PHARMACEUTICALLY ACCEPTABLE CLAYS NYCOMED IMAGING AS (NO) 1997-02-05 EP disclosed
WO-1996025182-A1 PROCESS OF PREPARING X-RAY CONTRAST COMPOSITIONS CONTAINING NANOPARTICLES NANOSYSTEMS L.L.C. (US) 1996-08-22 WO disclosed
US-5543133-A PREPARING PREMIX OF CONTRAST AGENT AND SURFACTANT; REDUCTION OF PARTICLE SIZE NANOSYSTEMS L.L.C. (US) 1996-08-06 US disclosed
US-5518187-A GRINDING PARTICLES OF DIAGNOSTIC IMAGING AGENT TO SUBMICRON SIZE WITH RIGID, SPHERICAL, POLYMER RESIN GRINDING MEDIA NANO SYSTEMS L.L.C. (US) 1996-05-21 US disclosed
WO-1995031973-A1 CONTINUOUS METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES NANOSYSTEMS L.L.C. (US) 1995-11-30 WO disclosed
WO-1995031974-A1 METHOD OF GRINDING PHARMACEUTICAL SUBSTANCES NANOSYSTEMS L.L.C. (US) 1995-11-30 WO disclosed
WO-1995028969-A1 X-RAY CONTRAST COMPOSITIONS CONTAINING PHARMACEUTICALLY ACCEPTABLE CLAYS NYCOMED IMAGING AS (NO) 1995-11-02 WO disclosed
US-5451393-A X-ray contrast compositions useful in medical imaging EASTMAN KODAK COMPANY (US) 1995-09-19 US disclosed
US-5318767-A X-ray contrast compositions useful in medical imaging STERLING WINTHROP INC. (US) 1994-06-07 US disclosed