Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 18/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774463 | 0.96 | MCHR1 (0.41) | ACACBHSD17B10 | |
| SCHEMBL8774602 | 0.94 | ACACB (0.39) | ACACBLMNAHTTCHRNB2CHRNB4 | |
| SCHEMBL8774095 | 0.92 | NR5A1 (0.41) | ACACBLMNAHTT | |
| SCHEMBL8775170 | 0.91 | CYP2D6 (0.46) | LMNAHTTHSD17B10 | |
| SCHEMBL8774805 | 0.89 | NQO1 (0.41) | ACACB | |
| SCHEMBL8775031 | 0.85 | CYP11B1 (0.39) | ACACBLMNAHSD17B10CHRNA7 | |
| SCHEMBL8774387 | 0.82 | APP (0.46) | ACACB | |
| SCHEMBL9154867 | 0.82 | ACACB (0.41) | ACACBLMNAHTTHSD17B10CHRNB2 | |
| SCHEMBL8774528 | 0.80 | ACACB (0.42) | ACACBHTTCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8774295 | 0.80 | FFAR1 (0.44) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |