Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 5/20 | 0.45 |
| ▸ | RARA | P10276 | 1/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774406 | 0.95 | RARB (0.50) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774481 | 0.95 | NFKB1 (0.44) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774337 | 0.91 | RAB9A (0.50) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774239 | 0.89 | HTR2A (0.50) | RAB9ASMN1; SMN2NPC1L3MBTL1RARB | |
| SCHEMBL8774800 | 0.89 | RARB (0.49) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774086 | 0.89 | RARB (0.49) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774132 | 0.88 | NPC1 (0.40) | RAB9ASMN1; SMN2NPC1L3MBTL1RARB | |
| SCHEMBL8775147 | 0.85 | NPC1 (0.47) | RAB9ASMN1; SMN2NPC1MAPTHSD17B10 | |
| SCHEMBL8774355 | 0.85 | RARB (0.55) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 | |
| SCHEMBL8774269 | 0.85 | RARB (0.55) | RAB9ASMN1; SMN2NPC1NFKB1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |